Buried water molecules contribute to the conformational stability of a protein
نویسندگان
چکیده
منابع مشابه
Contribution of water molecules in the interior of a protein to the conformational stability.
Water molecules frequently occur in the interior of globular proteins. To elucidate the contribution of buried water molecules to the conformational stability of a protein, we examined the crystal structures and the thermodynamic parameters of denaturation of six Ile to Ala/Gly mutant human lysozymes, in which a cavity is created at each mutation site by the substitution of a smaller side-chain...
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ژورنال
عنوان ژورنال: Protein Engineering, Design and Selection
سال: 2003
ISSN: 1741-0134,1741-0126
DOI: 10.1093/proeng/gzg001